Key clinical point: Ketamine quickly reduces suicidal ideation even in patients whose depressive symptoms are unresponsive.

Major finding: Ketamine infusions significantly reduced suicidal ideation even in patients whose treatment-resistant depression did not respond to the drug.

Data source: This ongoing observational study included 27 patients with treatment-resistant depression who received seven intravenous infusions of ketamine over roughly a 3-week period.

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