News & Media

How Depression and Antidepressant Drugs Work

Date: May 18, 2016 Source: Penn State Summary: New research demonstrates the effectiveness of ketamine to treat depression in a mouse model of the disease. The brings together two hypotheses: 1) that depression results from deficits in GABA signaling and 2) that depression results from deficits in glutamate signaling. It shows that the depression-like behavior […]


From Drug of Abuse to a Glimpse Into Depression

Date: May 18, 2016 Source: American Association of Pharmaceutical Scientists (AAPS) Summary: Ketamine, a synthetic analogue of PCP, has recently taken the spotlight as a novel, fast-acting antidepressant. However, experts say that more research on usage of ketamine as an antidepressant is needed.


Ketamine Lifts Depression via a Byproduct of its Metabolism

Date: May 4, 2016 Source: NIH/National Institute of Mental Health Summary: A chemical byproduct, or metabolite, created as the body breaks down ketamine likely holds the secret to its rapid antidepressant action. This metabolite singularly reversed depression-like behaviors in mice without triggering any of the anesthetic, dissociative, or addictive side effects associated with ketamine. The […]