News & Media

Street Drug ‘Special K’ May Offer New Hope For People With Treatment-Resistant Depression

A hallucinogenic drug known on the street as “Special K” offers new hope to those suffering from severe, treatment-resistant depression. Ketamine, which was originally developed in the 1960s as a milder version of PCP, already has a well-established medical use as a sedative or pain killer. But since 2000, small but high-quality studies have demonstrated […]

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Symptomatology and Predictors of Antidepressant Efficacy in Extended Responders to a Single Ketamine Infusion

Abstract BACKGROUND: Antidepressant response to a single sub-anesthetic dose infusion of the glutamatergic modulator ketamine is transient in most depressed patients; however, a minority continue to experience an extended response. This study examined depressive symptoms and potential clinical predictors of extended response to ketamine in subjects with mood disorders and found that a dissociative response […]

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Ketamine: 50 Years of Modulating the Mind

Abstract Ketamine was introduced into clinical practice in the 1960s and continues to be both clinically useful and scientifically fascinating. With considerably diverse molecular targets and neurophysiological properties, ketamine’s effects on the central nervous system remain incompletely understood. Investigators have leveraged the unique characteristics of ketamine to explore the invariant, fundamental mechanisms of anesthetic action. […]

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Ketamine Administration in Depressive Disorders: A Systematic Review and Meta-Analysis.

INTRODUCTION: Ketamine’s efficacy in depressive disorders has been established in several controlled trials. The aim of the present study was to determine whether or not ketamine administration significantly improves depressive symptomatology in depression and more specifically in major depressive disorder (MDD), bipolar depression, resistant depression (non-ECT studies), and as an anesthetic agent in electroconvulsive therapy […]

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How Depression and Antidepressant Drugs Work

Date: May 18, 2016 Source: Penn State Summary: New research demonstrates the effectiveness of ketamine to treat depression in a mouse model of the disease. The brings together two hypotheses: 1) that depression results from deficits in GABA signaling and 2) that depression results from deficits in glutamate signaling. It shows that the depression-like behavior […]

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From Drug of Abuse to a Glimpse Into Depression

Date: May 18, 2016 Source: American Association of Pharmaceutical Scientists (AAPS) Summary: Ketamine, a synthetic analogue of PCP, has recently taken the spotlight as a novel, fast-acting antidepressant. However, experts say that more research on usage of ketamine as an antidepressant is needed.

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