Articles about the MicroBiome from Lori Calabrese, MD | The Ketamine Blog

What is the microbiome?

The microbiome is the genetic material of a vast community of microorganisms such as bacteria, protozoa, viruses, and fungi that live in the gastrointestinal tract of your body. The combined genetic factors in this environment make up more than 200 times the genetic material in your own DNA. As such, this collection of microbes provide a strong influence over your digestion, immunity, and overall health.

In fact, for you to be at optimum health and wellbeing, these organisms must be in balance. When they are, they assist your digestion and strengthen your immunity.

What is “Balance” in the Microbiome?

There are harmful bacteria and other microbes as well as beneficial ones. As long as the “good” bacteria keep the “bad” bacteria from taking over, you can enjoy health and wellbeing. But if the good guys and bad guys shift out of balance, it can cause you to become very ill from a variety of diseases.

And along with diseases, depression and anxiety can also become unmanageable.

How do you strengthen the gut -brain axis?

To strengthen your microbiome, you can

  • increase the fiber in your diet
  • Eat as much fruits and vegetables as you can, choosing a wide variety and including all the colors available.
  • Choose high fiber vegetables in abundance like leeks, artichokes, garlic, and onions for their prebiotic fiber content. Some vegetables are low in fiber and actually have minimal nutritional value.  Lettuce falls in this category.
  • Seek out polyphenols, as in nuts, seeds, berries, olive oil, brassicas (cruciferous vegetables, mustard plants, and cabbages) coffee, and tea (green tea is best of all!)  These are antioxidants and fuel microbes.
  • Avoid snacking to give your microbiome a rest.
  • Make fermented foods a strong component of your daily diet. Foods like yogurt, kefir, sauerkraut, kimchee
  • Play in the dirt. Spend time in the country, work in your garden, and enjoy the earth and the fresh air. Doing so will diversify your microbiome and multiply the types of organisms there to improve your health, your immunity and your wellbeing.

These articles about the microbiome are offered to improve your understanding of the beneficial properties it possesses.

How What You’re Eating Affects Your Depression

Man laughing because he's feeling so much better since he started eating foods that fuel his brain.

We’ve talked before about how your diet affects your microbiome, and how your microbiome affects your mood. We’ve also talked about how eating foods rich in fatty acids helps your brain function. Since we know that your eating affects your depression—we know that… and you know that—let’s talk today about how other foods impact your […]


Side effects mild, brief with single antidepressant dose of intravenous ketamine

Safety data analyzed from five NIH inpatient clinical trials. National Institutes of Health researchers found that a single, low-dose ketamine infusion was relatively free of side effects for patients with treatment-resistant depression. Elia Acevedo-Diaz, M.D., Carlos Zarate, M.D., and colleagues at the NIH’s National Institute of Mental Health (NIMH) report their findings in the Journal of Affective […]


KRIYA Conference 2019: The Flexibility of Ketamine

Dr. Lori Calabrese speaks at KRIYA and applies the flexibility of ketamine.

We’ve come so far in ketamine treatment for depression, and we still have so far to go. KRIYA held the first conference on ketamine treatment for depression in 2015. Now, 5 years later, there are several medical conferences that support the exchange of information in this field. Raquel Bennett, the founder of KRIYA – The […]


Gratitude, Suicide Research Scientists, and the AFSP

Gratitude, suicide research scientists, and the AFSP help girls like this one find joy again.

Welcome to November… this is the month each year we dedicate to thankfulness and gratitude.  I’m going to share with you some experiences I’ve had this week with gratitude, suicide research scientists, and the AFSP. No matter where you are in life, no matter your circumstances…if you think about it..look around you…there is most likely […]


Get Your PUFAs Straight and Watch Your Mood Lift

Get your PUFAs straight so you can enjoy your moments like happy this young man.

We’re smack in the middle of a couple weeks focused on the quest for improved treatments for depression and anxiety.  This past Thursday was World Mental Health Day, dedicated to raising awareness for mental health …and this year’s efforts were focused on “40 seconds of action” to help reduce the risk of suicide. Because every […]


CT Psychiatrist Shows Titrated IV Ketamine Can STOP Suicidality

Data Published from a Real World Psychiatry Practice Shows How Ketamine Infusions Can Avert ER Trips and Hospitalizations SOUTH WINDSOR, Conn., Oct. 8, 2019 /PRNewswire/ — Lori Calabrese, M.D., Innovative Psychiatry (https://loricalabresemd.com). Local psychiatrist publishes data demonstrating that the use of a series of IV ketamine infusions, with dose adjustments, can stop suicidal thoughts and avert ER trips […]


APA IPS: Innovation and Collaboration Improve Access to Psychiatric Care

Dr. Calabrese's poster presentation about ketamine stopping suicidality and innovation and collaboration improve access to care.

I just returned from the annual meeting of the American Psychiatric Association’s Institute for Psychiatric Services: Mental Health Services Conference, in NYC. This conference was presented in collaboration with the World Psychiatric Association. The World Psychiatric Association represents 120,000 psychiatrists in 120 countries. The heart and focus was that innovation and collaboration improve access to […]