Innovative Psychiatry
The World Health Organization asserts that depression causes more disability worldwide than any other illness. In addition to standing alone as a disabling disorder, it also worsens other illnesses from diabetes, liver disease, heart disease, and brain injuries. We present these articles about depression to show the many ways this disorder is expressed, ways to treat it, and to dispel stigma caused by lack of information.
Depression and stress create a self-defeating cycle. Prolonged stress prunes the synapses, the dendrites attached to them, and the dendritic spines, reducing the network necessary for optimal signaling in the brain. Consequently, thinking slows and outlook darkens. In addition, creativity all but disappears. Depression follows this process, imposing yet more stress on the these all-important signaling structures.
Other structures in the brain enter the process. These structures in turn malfunction and make the symptoms worse. The lateral habenula, the amygdala, the thalamus, and the hippocampus each play a role in depression. By the same token, depression impacts them, too.
Only about a third of people who suffer with depression find relief with traditional antidepressants. These medicines increase neurotransmitters in the brain and eventually increase neuron growth. But the actions of these medicines delay the process and these patients improve slowly. Sometimes, if the first trial with a medication doesn’t help, a different one or combination can help another one third or so of those who didn’t feel better after the first trial. Unfortunately, 33% of people suffering from depression find no relief from these medications. Until recently, they were left with little or no hope of relief for the rest of their lives.
However, ketamine treatment is a novel and advanced treatment that has changed the prognosis for those treatment-resistant patients. Ketamine switches the mRNA to “On” which turns on the DNA to turboboost the brain-derived-neurotrophic-factor (BDNF) that proliferates neuronal growth along with synapses, dendrites, and dendritic spines which play such a vital role in improving signaling throughout the brain.
Another benefit of ketamine is how rapidly it causes the G proteins to slide off the lipid rafts in the cell membrane. This allows them to get back to work enhancing signals. It also causes the cell bursting in the lateral habenula to be dampened. Another process that allows you to experience a sense of reward – and feel better – when something good happens. Basically, ketamine treatment goes to work to help you feel better fast.
Then you enjoy clearer thinking and more creativity. Also a rewarding and upbeat outlook filled with light and joy. Add to that the improved initiative, increased motivation, and hope that makes life worth living again. This remarkable outcome occurs in 65-70% of treatment-resistant patients in general, and much more than that when the treatment is highly personalized. And the results are rapid and robust. Extraordinary.
As you read these articles about depression, keep in mind that there is always hope. Researchers continue to work to find more aspects ketamine’s effects on the brain that can impact the outcome.
Ethan was in his second semester of his first year in college. The new had worn off, and the classes were getting harder. He hadn’t had to work that hard to do well in high school and being challenged felt more like being overwhelmed. He studied hard for chemistry, but he really struggled to get […]
Jayne believed in being realistic. She didn’t notice that her “realistic” outlook leaned toward pessimism. When someone said, “Don’t be such a pessimist!” she would respond, “My realistic outlook has served me well.” She didn’t want her head in the clouds. When something bad happened, she thought about how it was punishment of her for […]
Tom woke up, his head pounding, and he ached all over. The dark cloud that followed him everywhere was back. The partying last night gave him a brief reprieve, but it was over. He slowly dragged himself out of bed and thought about how disappointing it was that he woke up. He didn’t realize he […]
Anxiety. Some people never struggle with it. A little bit of anxiety for them can be a motivator to study for a test, practice lines for a play, or learn math. Those who experience small spurts of anxiety can often perform very well. But when anxiety grows out of bounds it’s no longer motivating. When it […]
Shannon was 13 and woke up almost every morning disappointed to realize she was still alive. Her last thought before falling asleep was usually hoping, praying, she would not wake up in the morning. Her misery was difficult to describe but it involved every aspect of her life — parents and family, her school work, […]
Brittney dressed for school and left for the bus. She waited 20 minutes then slipped back into the house and slid under the bed. And she waited. She couldn’t face school…. all the kids who she felt judged her. The sleepiness that made it impossible to pay attention in class. The expectations from teachers she […]
Chronic Illness Creates Physical Stress Janie has a chronic illness that causes her to be admitted to the hospital — often the ICU — relatively frequently. Her condition becomes urgent, throwing her electrolyte balance, her pH balance, and her other systems into disarray. Each time she’s admitted, she suffers dreadfully with overwhelming nausea, vomiting…. and […]
Whether you’re expecting your first child or your kids are senior citizens themselves, your heart has been on your sleeve for the duration. Is there anything like being a mother? Whether you’re a. mother of a baby, a teen, or a mother of senior citizens, the worry never dissipates. They’re always on your mind. Here […]
It’s coming, and we’ll be there! This conference, hosted by Rupert McShane, Consultant Psychiatrist and Associate Professor, Oxford, UK will be a stunning international hybrid event and the list of speakers reads like the Who’s Who of the field. This is, quite simply, the most important and prestigious conference on ketamine and related compounds for […]
In addition to the suffering a new mother experiences from postpartum depression, the baby is at risk for lower IQ, increased likelihood of ADHD, slower language development, and increased risk of behavior problems and other psychiatric disorders. Indicators for postpartum depression — or risk factors, as we might call them — can be identified and […]